GM-CSF Protects Macrophages from DNA Damage by Inducing Differentiation

GM-CSF Protects Macrophages from DNA Damage by Inducing Differentiation

At inflammatory loci, pro-inflammatory activation of macrophages produces large amounts of reactive oxygen species (ROS) that induce DNA breaks and apoptosis. Given that M-CSF and GM-CSF induce two different pathways in macrophages, one for proliferation and the other for survival, in this study we...

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Bibliographic Details
Main Authors: Tania Vico, Catrin Youssif, Fathema Zare, Mònica Comalada, Carlos Sebastian, Jorge Lloberas, Antonio Celada
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cells
Subjects:
macrophage
growth factors
proliferation
differentiation
DNA damage
Online Access:https://www.mdpi.com/2073-4409/11/6/935

Internet

https://www.mdpi.com/2073-4409/11/6/935

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