Beneficial effects of sound exposure on auditory cortex development in a mouse model of Fragile X Syndrome

Beneficial effects of sound exposure on auditory cortex development in a mouse model of Fragile X Syndrome

Background: Fragile X syndrome (FXS) is the most common genetic cause of autism and intellectual disability. Fragile X mental retardation gene (Fmr1) knock-out (KO) mice display core deficits of FXS, including abnormally increased sound-evoked responses, and show a delayed development of parvalbumin...

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Bibliographic Details
Main Authors: Anna O. Kulinich, Sarah M. Reinhard, Maham Rais, Jonathan W. Lovelace, Veronica Scott, Devin K. Binder, Khaleel A. Razak, Iryna M. Ethell
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Neurobiology of Disease
Subjects:
Fragile X Syndrome
Autism
Auditory cortex
Parvalbumin interneurons
Perineuronal nets
Sensory hypersensitivity
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119302979

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http://www.sciencedirect.com/science/article/pii/S0969996119302979

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