Lineage skewing and genome instability underlie marrow failure in a zebrafish model of GATA2 deficiency

Lineage skewing and genome instability underlie marrow failure in a zebrafish model of GATA2 deficiency

Summary: Inherited bone marrow failure associated with heterozygous mutations in GATA2 predisposes toward hematological malignancies, but the mechanisms remain poorly understood. Here, we investigate the mechanistic basis of marrow failure in a zebrafish model of GATA2 deficiency. Single-cell transc...

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Bibliographic Details
Main Authors: Christopher B. Mahony, Lucy Copper, Pavle Vrljicak, Boris Noyvert, Chrystala Constantinidou, Sofia Browne, Yi Pan, Claire Palles, Sascha Ott, Martin R. Higgs, Rui Monteiro
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Cell Reports
Subjects:
CP: Molecular biology
CP: Stem cell research
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472300582X

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http://www.sciencedirect.com/science/article/pii/S221112472300582X

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