Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors.

Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors.

Frameshift and nonsense mutations are common in tumors with microsatellite instability, and mRNAs from these mutated genes have premature termination codons (PTCs). Abnormal mRNAs containing PTCs are normally degraded by the nonsense-mediated mRNA decay (NMD) system. However, PTCs located within 50-...

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Bibliographic Details
Main Authors: Kwon Tae You, Long Shan Li, Nam-Gyun Kim, Hyun Ju Kang, Kwi Hye Koh, Yong-Joon Chwae, Kyoung Mi Kim, Yoon Ki Kim, Sung Mi Park, Sung Key Jang, Hoguen Kim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-05-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.0050109

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https://doi.org/10.1371/journal.pbio.0050109

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