Effects of Apolipoprotein E polymorphism on carotid intima-media thickness, incident myocardial infarction and incident stroke
Abstract The Apolipoprotein E (APOE) gene polymorphism (rs429358 and rs7412) shows a well-established association with lipid profiles, but its effect on cardiovascular disease is still conflicting. Therefore, we examined the association of different APOE alleles with common carotid artery intima-med...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-03-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-09129-5 |
| _version_ | 1811335413342666752 |
|---|---|
| author | Anitha Pitchika Marcello Ricardo Paulista Markus Sabine Schipf Alexander Teumer Sandra Van der Auwera Matthias Nauck Marcus Dörr Stephan Felix Hans-Jörgen Grabe Henry Völzke Till Ittermann |
| author_facet | Anitha Pitchika Marcello Ricardo Paulista Markus Sabine Schipf Alexander Teumer Sandra Van der Auwera Matthias Nauck Marcus Dörr Stephan Felix Hans-Jörgen Grabe Henry Völzke Till Ittermann |
| author_sort | Anitha Pitchika |
| collection | DOAJ |
| description | Abstract The Apolipoprotein E (APOE) gene polymorphism (rs429358 and rs7412) shows a well-established association with lipid profiles, but its effect on cardiovascular disease is still conflicting. Therefore, we examined the association of different APOE alleles with common carotid artery intima-media thickness (CCA-IMT), carotid plaques, incident myocardial infarction (MI) and stroke. We analyzed data from 3327 participants aged 20–79 years of the population-based Study of Health in Pomerania (SHIP) from Northeast Germany with a median follow-up time of 14.5 years. Linear, logistic, and Cox-regression models were used to assess the associations of the APOE polymorphism with CCA-IMT, carotid plaques, incident MI and stroke, respectively. In our study, the APOE E2 allele was associated with lower CCA-IMT at baseline compared to E3 homozygotes (β: − 0.02 [95% CI − 0.04, − 0.004]). Over the follow-up, 244 MI events and 218 stroke events were observed. APOE E2 and E4 allele were not associated with incident MI (E2 HR: 1.06 [95% CI 0.68, 1.66]; E4 HR: 1.03 [95% CI 0.73, 1.45]) and incident stroke (E2 HR: 0.79 [95% CI 0.48, 1.30]; E4 HR: 0.96 [95% CI 0.66, 1.38]) in any of the models adjusting for potential confounders. However, the positive association between CCA-IMT and incident MI was more pronounced in E2 carriers than E3 homozygotes. Thus, our study suggests that while APOE E2 allele may predispose individuals to lower CCA-IMT, E2 carriers may be more prone to MI than E3 homozygotes as the CCA-IMT increases. APOE E4 allele had no effect on CCA-IMT, plaques, MI or stroke. |
| first_indexed | 2024-04-13T17:23:49Z |
| format | Article |
| id | doaj.art-10987494f7464a88901302845499a59f |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T17:23:49Z |
| publishDate | 2022-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-10987494f7464a88901302845499a59f2022-12-22T02:37:51ZengNature PortfolioScientific Reports2045-23222022-03-0112111010.1038/s41598-022-09129-5Effects of Apolipoprotein E polymorphism on carotid intima-media thickness, incident myocardial infarction and incident strokeAnitha Pitchika0Marcello Ricardo Paulista Markus1Sabine Schipf2Alexander Teumer3Sandra Van der Auwera4Matthias Nauck5Marcus Dörr6Stephan Felix7Hans-Jörgen Grabe8Henry Völzke9Till Ittermann10Institute for Community Medicine, University Medicine Greifswald, SHIP/Clinical-Epidemiological ResearchDepartment of Internal Medicine B, University Medicine GreifswaldInstitute for Community Medicine, University Medicine Greifswald, SHIP/Clinical-Epidemiological ResearchInstitute for Community Medicine, University Medicine Greifswald, SHIP/Clinical-Epidemiological ResearchDepartment of Psychiatry and Psychotherapy, University Medicine GreifswaldGerman Center for Cardiovascular Research (DZHK E.V.), Partner site GreifswaldDepartment of Internal Medicine B, University Medicine GreifswaldDepartment of Internal Medicine B, University Medicine GreifswaldDepartment of Psychiatry and Psychotherapy, University Medicine GreifswaldInstitute for Community Medicine, University Medicine Greifswald, SHIP/Clinical-Epidemiological ResearchInstitute for Community Medicine, University Medicine Greifswald, SHIP/Clinical-Epidemiological ResearchAbstract The Apolipoprotein E (APOE) gene polymorphism (rs429358 and rs7412) shows a well-established association with lipid profiles, but its effect on cardiovascular disease is still conflicting. Therefore, we examined the association of different APOE alleles with common carotid artery intima-media thickness (CCA-IMT), carotid plaques, incident myocardial infarction (MI) and stroke. We analyzed data from 3327 participants aged 20–79 years of the population-based Study of Health in Pomerania (SHIP) from Northeast Germany with a median follow-up time of 14.5 years. Linear, logistic, and Cox-regression models were used to assess the associations of the APOE polymorphism with CCA-IMT, carotid plaques, incident MI and stroke, respectively. In our study, the APOE E2 allele was associated with lower CCA-IMT at baseline compared to E3 homozygotes (β: − 0.02 [95% CI − 0.04, − 0.004]). Over the follow-up, 244 MI events and 218 stroke events were observed. APOE E2 and E4 allele were not associated with incident MI (E2 HR: 1.06 [95% CI 0.68, 1.66]; E4 HR: 1.03 [95% CI 0.73, 1.45]) and incident stroke (E2 HR: 0.79 [95% CI 0.48, 1.30]; E4 HR: 0.96 [95% CI 0.66, 1.38]) in any of the models adjusting for potential confounders. However, the positive association between CCA-IMT and incident MI was more pronounced in E2 carriers than E3 homozygotes. Thus, our study suggests that while APOE E2 allele may predispose individuals to lower CCA-IMT, E2 carriers may be more prone to MI than E3 homozygotes as the CCA-IMT increases. APOE E4 allele had no effect on CCA-IMT, plaques, MI or stroke.https://doi.org/10.1038/s41598-022-09129-5 |
| spellingShingle | Anitha Pitchika Marcello Ricardo Paulista Markus Sabine Schipf Alexander Teumer Sandra Van der Auwera Matthias Nauck Marcus Dörr Stephan Felix Hans-Jörgen Grabe Henry Völzke Till Ittermann Effects of Apolipoprotein E polymorphism on carotid intima-media thickness, incident myocardial infarction and incident stroke Scientific Reports |
| title | Effects of Apolipoprotein E polymorphism on carotid intima-media thickness, incident myocardial infarction and incident stroke |
| title_full | Effects of Apolipoprotein E polymorphism on carotid intima-media thickness, incident myocardial infarction and incident stroke |
| title_fullStr | Effects of Apolipoprotein E polymorphism on carotid intima-media thickness, incident myocardial infarction and incident stroke |
| title_full_unstemmed | Effects of Apolipoprotein E polymorphism on carotid intima-media thickness, incident myocardial infarction and incident stroke |
| title_short | Effects of Apolipoprotein E polymorphism on carotid intima-media thickness, incident myocardial infarction and incident stroke |
| title_sort | effects of apolipoprotein e polymorphism on carotid intima media thickness incident myocardial infarction and incident stroke |
| url | https://doi.org/10.1038/s41598-022-09129-5 |
| work_keys_str_mv | AT anithapitchika effectsofapolipoproteinepolymorphismoncarotidintimamediathicknessincidentmyocardialinfarctionandincidentstroke AT marcelloricardopaulistamarkus effectsofapolipoproteinepolymorphismoncarotidintimamediathicknessincidentmyocardialinfarctionandincidentstroke AT sabineschipf effectsofapolipoproteinepolymorphismoncarotidintimamediathicknessincidentmyocardialinfarctionandincidentstroke AT alexanderteumer effectsofapolipoproteinepolymorphismoncarotidintimamediathicknessincidentmyocardialinfarctionandincidentstroke AT sandravanderauwera effectsofapolipoproteinepolymorphismoncarotidintimamediathicknessincidentmyocardialinfarctionandincidentstroke AT matthiasnauck effectsofapolipoproteinepolymorphismoncarotidintimamediathicknessincidentmyocardialinfarctionandincidentstroke AT marcusdorr effectsofapolipoproteinepolymorphismoncarotidintimamediathicknessincidentmyocardialinfarctionandincidentstroke AT stephanfelix effectsofapolipoproteinepolymorphismoncarotidintimamediathicknessincidentmyocardialinfarctionandincidentstroke AT hansjorgengrabe effectsofapolipoproteinepolymorphismoncarotidintimamediathicknessincidentmyocardialinfarctionandincidentstroke AT henryvolzke effectsofapolipoproteinepolymorphismoncarotidintimamediathicknessincidentmyocardialinfarctionandincidentstroke AT tillittermann effectsofapolipoproteinepolymorphismoncarotidintimamediathicknessincidentmyocardialinfarctionandincidentstroke |