Screening of Yeast Display Libraries of Enzymatically Treated Peptides to Discover Macrocyclic Peptide Ligands

Screening of Yeast Display Libraries of Enzymatically Treated Peptides to Discover Macrocyclic Peptide Ligands

We present the construction and screening of yeast display libraries of post-translationally modified peptides wherein site-selective enzymatic treatment of linear peptides is achieved using bacterial transglutaminase. To this end, we developed two alternative routes, namely (i) yeast display of lin...

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Bibliographic Details
Main Authors: John Bowen, John Schneible, Kaitlyn Bacon, Collin Labar, Stefano Menegatti, Balaji M. Rao
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
yeast display library
cyclic peptide
Yes Associated Protein (YAP) 65
WW domain
transglutaminase
Online Access:https://www.mdpi.com/1422-0067/22/4/1634

Internet

https://www.mdpi.com/1422-0067/22/4/1634

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