Desmoglein2 Regulates Claudin2 Expression by Sequestering PI-3-Kinase in Intestinal Epithelial Cells

Desmoglein2 Regulates Claudin2 Expression by Sequestering PI-3-Kinase in Intestinal Epithelial Cells

Inflammation-induced reduction of intestinal desmosomal cadherin Desmoglein 2 (Dsg2) is linked to changes of tight junctions (TJ) leading to impaired intestinal epithelial barrier (IEB) function by undefined mechanisms. We characterized the interplay between loss of Dsg2 and upregulation of pore-for...

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Bibliographic Details
Main Authors: Natalie Burkard, Michael Meir, Felix Kannapin, Christoph Otto, Maximilian Petzke, Christoph-Thomas Germer, Jens Waschke, Nicolas Schlegel
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
Claudin2
Dsg2
inflammation
intestinal barrier
PI-3-kinase
inflammatory bowel disease
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.756321/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.756321/full

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