Dynamic monitoring of cerebrospinal fluid circulating tumor DNA to identify unique genetic profiles of brain metastatic tumors and better predict intracranial tumor responses in non-small cell lung cancer patients with brain metastases: a prospective cohort study (GASTO 1028)

Dynamic monitoring of cerebrospinal fluid circulating tumor DNA to identify unique genetic profiles of brain metastatic tumors and better predict intracranial tumor responses in non-small cell lung cancer patients with brain metastases: a prospective cohort study (GASTO 1028)

Abstract Background Due to the blood-brain barrier, plasma is not an ideal source to evaluate the genetic characteristics of central nervous system tumors. Thus, cerebrospinal fluid (CSF) is becoming an alternative biopsy type to evaluate the genetic landscape of intracranial tumors. We aimed to exp...

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Bibliographic Details
Main Authors: Meichen Li, Jing Chen, Baishen Zhang, Juan Yu, Na Wang, Delan Li, Yang Shao, Dongqin Zhu, Chuqiao Liang, Yutong Ma, Qiuxiang Ou, Xue Hou, Likun Chen
Format: Article
Language:English
Published: BMC 2022-11-01
Series:BMC Medicine
Subjects:
Cerebrospinal fluid
Circulating tumor DNA
Brain metastases
Intracranial response
Clonal evolution
Online Access:https://doi.org/10.1186/s12916-022-02595-8

Internet

https://doi.org/10.1186/s12916-022-02595-8

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