Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids

Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids

Transport of biologically active molecules across tight epithelial barriers is a major challenge preventing therapeutic peptides from oral drug delivery. Here, we identify a set of synthetic glycosphingolipids that harness the endogenous process of intracellular lipid-sorting to enable mucosal absor...

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Bibliographic Details
Main Authors: Maria Daniela Garcia-Castillo, Daniel J-F Chinnapen, Yvonne M te Welscher, Rodrigo J Gonzalez, Samir Softic, Michele Pacheco, Randall J Mrsny, C Ronald Kahn, Ulrich H von Andrian, Jesper Lau, Bradley L Pentelute, Wayne I Lencer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-05-01
Series:eLife
Subjects:
glycolipids/gangliosides
lipid sorting
drug delivery
GLP-1/ diabetes
membrane transport
epithelial cells
Online Access:https://elifesciences.org/articles/34469

Internet

https://elifesciences.org/articles/34469

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