Targeted RNA-Based Oxford Nanopore Sequencing for Typing 12 Classical HLA Genes

Targeted RNA-Based Oxford Nanopore Sequencing for Typing 12 Classical HLA Genes

Identification of human leukocyte antigen (HLA) alleles from next-generation sequencing (NGS) data is challenging because of the high polymorphism and mosaic nature of HLA genes. Owing to the complex nature of HLA genes and consequent challenges in allele assignment, Oxford Nanopore Technologies’ (O...

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Bibliographic Details
Main Authors: Tiira Johansson, Satu Koskela, Dawit A. Yohannes, Jukka Partanen, Päivi Saavalainen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Genetics
Subjects:
human leukocyte antigen
HLA genotyping
nanopore sequencing
RNA sequencing
MinION
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.635601/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2021.635601/full

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