Synthesis and Activity of Triazole-Adenosine Analogs as Protein Arginine Methyltransferase 5 Inhibitors

Synthesis and Activity of Triazole-Adenosine Analogs as Protein Arginine Methyltransferase 5 Inhibitors

Protein arginine methyltransferase 5 (PRMT5) is an attractive molecular target in anticancer drug discovery due to its extensive involvement in transcriptional control, RNA processing, and other cellular pathways that are causally related to tumor initiation and progression. In recent years, various...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Tyler Brown, Mengtong Cao, Y. George Zheng
Format: Artykuł
Język:English
Wydane: MDPI AG 2022-06-01
Seria:Molecules
Hasła przedmiotowe:
epigenetics
arginine methylation
PRMT5
click chemistry
inhibitor
SAM analog
Dostęp online:https://www.mdpi.com/1420-3049/27/12/3779

Internet

https://www.mdpi.com/1420-3049/27/12/3779

Podobne zapisy