LARP4 mRNA codon-tRNA match contributes to LARP4 activity for ribosomal protein mRNA poly(A) tail length protection

LARP4 mRNA codon-tRNA match contributes to LARP4 activity for ribosomal protein mRNA poly(A) tail length protection

Messenger RNA function is controlled by the 3' poly(A) tail (PAT) and poly(A)-binding protein (PABP). La-related protein-4 (LARP4) binds poly(A) and PABP. LARP4 mRNA contains a translation-dependent, coding region determinant (CRD) of instability that limits its expression. Although the CRD com...

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Bibliographic Details
Main Authors: Sandy Mattijssen, Aneeshkumar G Arimbasseri, James R Iben, Sergei Gaidamakov, Joowon Lee, Markus Hafner, Richard J Maraia
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-09-01
Series:eLife
Subjects:
wobble decoding
mouse
anticodon
Online Access:https://elifesciences.org/articles/28889

Internet

https://elifesciences.org/articles/28889

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