Decitabine-Mediated Upregulation of CSPG4 in Ovarian Carcinoma Cells Enables Targeting by CSPG4-Specific CAR-T Cells

The addition of CAR-T cells to the armamentarium of immunotherapy revigorated the field of oncology by inducing long-lasting remissions in patients with relapsing/refractory hematological malignancies. Nevertheless, in the lion’s share of patients diagnosed with solid tumors, CAR-T-cell therapy so f...

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Bibliographic Details
Main Authors: Dennis Christoph Harrer, Charlotte Schenkel, Carola Berking, Wolfgang Herr, Hinrich Abken, Jan Dörrie, Niels Schaft
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cancers
Subjects:
Online Access:https://www.mdpi.com/2072-6694/14/20/5033