Modulation of the Tumor Microenvironment by Ellagic Acid in Rat Model for Hepatocellular Carcinoma: A Potential Target against Hepatic Cancer Stem Cells

Modulation of the Tumor Microenvironment by Ellagic Acid in Rat Model for Hepatocellular Carcinoma: A Potential Target against Hepatic Cancer Stem Cells

The resistance to therapy and relapse in hepatocellular carcinoma (HCC) is highly attributed to hepatic cancer stem cells (HCSCs). HCSCs are under microenvironment control. This work aimed to assess the systemic effect of ellagic acid (EA) on the HCC microenvironment to decline HCSCs. Fifty Wistar r...

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Bibliographic Details
Main Authors: Wafaa S. Ramadan, Saleh Alkarim, Mohammed Moulay, Ghadeer Alrefeai, Fatma Alkudsy, Khalid Rehman Hakeem, Ashwaq Iskander
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Cancers
Subjects:
CSCs
HCC rat model
TGF alpha
TGF beta
VEGF
apoptosis
Online Access:https://www.mdpi.com/2072-6694/15/19/4891

Internet

https://www.mdpi.com/2072-6694/15/19/4891

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