Unveiling the dimer/monomer propensities of Smad MH1-DNA complexes

Unveiling the dimer/monomer propensities of Smad MH1-DNA complexes

Smad transcription factors are the main downstream effectors of the Transforming growth factor β superfamily (TGFβ) signalling network. The DNA complexes determined here by X-ray crystallography for the Bone Morphogenetic Proteins (BMP) activated Smad5 and Smad8 proteins reveal that all MH1 domains...

Full description

Bibliographic Details
Main Authors:	Lidia Ruiz, Zuzanna Kaczmarska, Tiago Gomes, Eric Aragon, Carles Torner, Regina Freier, Blazej Baginski, Pau Martin-Malpartida, Natàlia de Martin Garrido, José. A. Marquez, Tiago N. Cordeiro, Radoslaw Pluta, Maria J. Macias
Format:	Article
Language:	English
Published:	Elsevier 2021-01-01
Series:	Computational and Structural Biotechnology Journal
Subjects:	Smad Transcription factor Protein-DNA MH1 domain BMP signaling Smad5
Online Access:	http://www.sciencedirect.com/science/article/pii/S2001037021000027

Similar Items

The effects of mouse ovarian granulosa cell function and related gene expression by suppressing BMP/Smad signaling pathway
by: Li Zhang, et al.
Published: (2018-09-01)

Xbra modulates the activity of linker region phosphorylated Smad1 during Xenopus development
by: Santosh Kumar, et al.
Published: (2024-04-01)

Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination
by: Feng Xie, et al.
Published: (2014-10-01)

Dioxinodehydroeckol Enhances the Differentiation of Osteoblasts by Regulating the Expression of Phospho-Smad1/5/8
by: Byul-Nim Ahn, et al.
Published: (2016-09-01)

Dusp1 modulates activin/smad2 mediated germ layer specification via FGF signal inhibition in Xenopus embryos
by: Zobia Umair, et al.
Published: (2020-11-01)

Ataluren prevented bone loss induced by ovariectomy and aging in mice through the BMP-SMAD signaling pathway
by: Lijun Zeng, et al.
Published: (2023-10-01)

A study of Smad4, Smad6 and Smad7 in Surgically Resected Samples of Pancreatic Ductal Adenocarcinoma and Their Correlation with Clinicopathological Parameters and Patient Survival
by: Singh Puneet, et al.
Published: (2011-12-01)

The role of green peas protein hydrolysate in TGF/SMAD signaling to prevent renal fibrosis
by: Meilinah Hidayat, et al.
Published: (2022-06-01)

Investigation of SMAD3 and SMAD4 Genes Expression in CML Patients and K562 Cell Line
by: T Mahdloo, et al.
Published: (2023-04-01)

Pharmacological Manipulation of Early Zebrafish Skeletal Development Shows an Important Role for Smad9 in Control of Skeletal Progenitor Populations
by: Georgina L. K. McDonald, et al.
Published: (2021-02-01)

Smad8 Is Increased in Duchenne Muscular Dystrophy and Suppresses miR-1, miR-133a, and miR-133b
by: Michael A. Lopez, et al.
Published: (2022-07-01)

Differential Role of Smad2 and Smad3 in the Acquisition of an Endovascular Trophoblast-Like Phenotype and Preeclampsia
by: Jelena Brkić, et al.
Published: (2020-07-01)

YAP/TAZ regulates TGF-β/Smad3 signaling by induction of Smad7 via AP-1 in human skin dermal fibroblasts
by: Zhaoping Qin, et al.
Published: (2018-04-01)

Transcriptional regulation of cyclophilin D by BMP/Smad signaling and its role in osteogenic differentiation
by: Rubens Sautchuk, et al.
Published: (2022-05-01)

Baicalin protects against renal interstitial fibrosis in mice by inhibiting the TGF-β/Smad signalling pathway
by: Hui Wang, et al.
Published: (2022-12-01)

Conservation and evolutionary divergence in the activity of receptor-regulated smads
by: Sorrentino Gina M, et al.
Published: (2012-10-01)

DACT3 promotes ferroptosis of glioma cells through activating BMP4/Smad signaling pathway
by: ZHENG Li, et al.
Published: (2023-07-01)

Characterization of Wnt/β-catenin and BMP/Smad signaling pathways in an in vitro model of amyotrophic lateral sclerosis
by: Cristina ePinto, et al.
Published: (2013-12-01)

Smad2/3 Activation Regulates Smad1/5/8 Signaling via a Negative Feedback Loop to Inhibit 3T3-L1 Adipogenesis
by: Senem Aykul, et al.
Published: (2021-08-01)

Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors
by: Oddrun Elise Olsen, et al.
Published: (2020-03-01)

BMP3 suppresses colon tumorigenesis via ActRIIB/SMAD2-dependent and TAK1/JNK signaling pathways
by: Jialing Wen, et al.
Published: (2019-10-01)

Analysis of the SMAD4 gene in asthma
by: Miletic Aleksandra, et al.
Published: (2014-12-01)

Assessment of the Role of Selected SMAD3 and SMAD4 Genes Polymorphisms in the Development of Colorectal Cancer: Preliminary Research
by: Wosiak A, et al.
Published: (2021-01-01)

Retinoids Promote Mouse Bone Marrow-Derived Macrophage Differentiation and Efferocytosis via Upregulating Bone Morphogenetic Protein-2 and Smad3
by: Éva Fige, et al.
Published: (2022-09-01)

Quantitative analysis of transcriptome dynamics provides novel insights into developmental state transitions
by: Kristin Johnson, et al.
Published: (2022-10-01)

Efficient retina formation requires suppression of both Activin and BMP signaling pathways in pluripotent cells
by: Kimberly A. Wong, et al.
Published: (2015-03-01)

Naotaifang formula attenuates OGD/R-induced inflammation and ferroptosis by regulating microglial M1/M2 polarization through BMP6/SMADs signaling pathway
by: Jun Liao, et al.
Published: (2023-11-01)

BMP Signaling Pathway in Dentin Development and Diseases
by: Mengmeng Liu, et al.
Published: (2022-07-01)

Targeting SMAD-Dependent Signaling: Considerations in Epithelial and Mesenchymal Solid Tumors
by: Farhana Runa, et al.
Published: (2024-03-01)

Expression and Polymorphisms of <i>SMAD1</i>, <i>SMAD2</i> and <i>SMAD3</i> Genes and Their Association with Litter Size in Tibetan Sheep (<i>Ovis aries</i>)
by: Mingming Li, et al.
Published: (2022-12-01)

Smad2/4 Signaling Pathway Is Critical for Epidermal Langerhans Cell Repopulation Under Inflammatory Condition but Not Required for Their Homeostasis at Steady State
by: Linting Huang, et al.
Published: (2020-05-01)

Molecular Characterization, Expression Profiles of <i>SMAD4</i>, <i>SMAD5</i> and <i>SMAD7</i> Genes and Lack of Association with Litter Size in Tibetan Sheep
by: Ruizhe Sun, et al.
Published: (2022-08-01)

Chordin-Like 1 Improves Osteogenesis of Bone Marrow Mesenchymal Stem Cells Through Enhancing BMP4-SMAD Pathway
by: Tao Liu, et al.
Published: (2019-06-01)

Role of SMAD signaling in drug-induced apoptosis in colon cancer
by: Bin Ren, et al.
Published: (2014-10-01)

FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells
by: Ingrid Quist-Løkken, et al.
Published: (2023-01-01)

miR-1323 suppresses bone mesenchymal stromal cell osteogenesis and fracture healing via inhibiting BMP4/SMAD4 signaling
by: Hui Xie, et al.
Published: (2020-06-01)

Smad3 Mediates Diabetic Dyslipidemia and Fatty Liver in db/db Mice by Targeting PPARδ
by: Huijun He, et al.
Published: (2023-07-01)

Fstl1 Promotes Glioma Growth Through the BMP4/Smad1/5/8 Signaling Pathway
by: Xin Jin, et al.
Published: (2017-12-01)

Brain arteriovenous malformation in hereditary hemorrhagic telangiectasia: Recent advances in cellular and molecular mechanisms
by: Elise Drapé, et al.
Published: (2022-11-01)

The Role of the TGF-β Superfamily in Myocardial Infarction
by: Anis Hanna, et al.
Published: (2019-09-01)