Serum Level of Antibodies (IgG, IgM) Against Benzo[a]pyrene-7,8-diol-9,10-epoxide-DNA Adducts in Children Dermatologically Exposed to Coal Tar

Serum Level of Antibodies (IgG, IgM) Against Benzo[a]pyrene-7,8-diol-9,10-epoxide-DNA Adducts in Children Dermatologically Exposed to Coal Tar

Crude coal tar (CCT) contains polycyclic aromatic hydrocarbons (PAHs). Benzo[a]pyrene (BaP) is metabolized into a highly reactive metabolite benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE) that is able to bind to DNA and creates BPDE-DNA adducts. Adducted DNA becomes immunogenic and induces immune respo...

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Bibliographic Details
Main Authors: Pavel Borský, Ctirad Andrýs, Jan Krejsek, Květoslava Hamáková, Jan Kremláček, Andrea Málková, Lenka Bartošová, Zdeněk Fiala, Vladimír Palička, Lenka Borská
Format: Article
Language:English
Published: Karolinum Press 2017-06-01
Series:Acta Medica
Subjects:
polycyclic aromatic hydrocarbons
coal tar
BPDE-DNA adducts
antibodies
psoriasis
goeckerman therapy
children
Online Access:https://actamedica.lfhk.cuni.cz/60/1/0027/

Internet

https://actamedica.lfhk.cuni.cz/60/1/0027/

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