Inhibitors of the Transcription Factor STAT3 Decrease Growth and Induce Immune Response Genes in Models of Malignant Pleural Mesothelioma (MPM)

Inhibitors of the Transcription Factor STAT3 Decrease Growth and Induce Immune Response Genes in Models of Malignant Pleural Mesothelioma (MPM)

Malignant pleural mesothelioma (MPM) is an aggressive cancer defined by loss-of-function mutations with few therapeutic options. We examined the contribution of the transcription factor Signal transducer and activator of transcription 3 (STAT3) to cell growth and gene expression in preclinical model...

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Bibliographic Details
Main Authors: Moshe Lapidot, Abigail E. Case, Dalia Larios, Helen I. Gandler, Chengcheng Meng, Isidora Tošić, Ellen L. Weisberg, Michael J. Poitras, Prafulla C. Gokhale, Cloud P. Paweletz, Klaus Podar, Ravi Salgia, Srinivas V. Saladi, James D. Griffin, David A. Frank, Raphael Bueno, Martin Sattler
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cancers
Subjects:
malignant pleural mesothelioma
STAT3
targeted therapy
aberrant signal transduction
Online Access:https://www.mdpi.com/2072-6694/13/1/7

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https://www.mdpi.com/2072-6694/13/1/7

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