Depletion of Fumarate Hydratase, an Essential TCA Cycle Enzyme, Drives Proliferation in a Two-Step Model

Depletion of Fumarate Hydratase, an Essential TCA Cycle Enzyme, Drives Proliferation in a Two-Step Model

Fumarate hydratase (FH) is an evolutionary conserved TCA cycle enzyme that reversibly catalyzes the hydration of fumarate to L-malate and has a moonlight function in the DNA damage response (DDR). Interestingly, FH has a contradictory cellular function, as it is pro-survival through its role in the...

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Bibliographic Details
Main Authors: Balakrishnan Solaimuthu, Michal Lichtenstein, Arata Hayashi, Anees Khatib, Inbar Plaschkes, Yuval Nevo, Mayur Tanna, Ophry Pines, Yoav D. Shaul
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cancers
Subjects:
cancer metabolism
DNA damage
fumarate hydratase
TCA cycle
Online Access:https://www.mdpi.com/2072-6694/14/22/5508

Internet

https://www.mdpi.com/2072-6694/14/22/5508

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