Peiminine Induces G0/G1-Phase Arrest, Apoptosis, and Autophagy via the ROS/JNK Signaling Pathway in Human Osteosarcoma Cells in Vitro and in Vivo

Peiminine Induces G0/G1-Phase Arrest, Apoptosis, and Autophagy via the ROS/JNK Signaling Pathway in Human Osteosarcoma Cells in Vitro and in Vivo

Aims: Peiminine has been reported to have various pharmacological properties, including anticancer activity. In this study, we investigated the effect of this alkaloid on osteosarcoma and explored the underlying mechanisms.Methods: To evaluate the antiosteosarcoma effects of peiminine in vitro, cell...

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Bibliographic Details
Main Authors: Lei Yu, Yuxi Chen, Shaohui Yuan, Yang Cao, Zhenggang Bi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Pharmacology
Subjects:
peiminine
apoptosis
autophagy
reactive oxygen species ROS
c-Jun N-terminal kinase JNK
osteosarcoma
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.770846/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.770846/full

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