MYH10 activation rescues contractile defects in arrhythmogenic cardiomyopathy (ACM)

MYH10 activation rescues contractile defects in arrhythmogenic cardiomyopathy (ACM)

Abstract The most prevalent genetic form of inherited arrhythmogenic cardiomyopathy (ACM) is caused by mutations in desmosomal plakophilin-2 (PKP2). By studying pathogenic deletion mutations in the desmosomal protein PKP2, here we identify a general mechanism by which PKP2 delocalization restricts a...

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Bibliographic Details
Main Authors: Nieves García-Quintáns, Silvia Sacristán, Cristina Márquez-López, Cristina Sánchez-Ramos, Fernando Martinez-de-Benito, David Siniscalco, Andrés González-Guerra, Emilio Camafeita, Marta Roche-Molina, Mariya Lytvyn, David Morera, María I. Guillen, María A. Sanguino, David Sanz-Rosa, Daniel Martín-Pérez, Ricardo Garcia, Juan A. Bernal
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41981-5

Internet

https://doi.org/10.1038/s41467-023-41981-5

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