Association of <i>SLC22A1</i>, <i>SLC22A2</i>, <i>SLC47A1</i>, and <i>SLC47A2</i> Polymorphisms with Metformin Efficacy in Type 2 Diabetic Patients

Association of <i>SLC22A1</i>, <i>SLC22A2</i>, <i>SLC47A1</i>, and <i>SLC47A2</i> Polymorphisms with Metformin Efficacy in Type 2 Diabetic Patients

Response to metformin, first-line therapy for type 2 diabetes mellitus (T2DM), exists interindividual variation. Considering that transporters belonging to the solute carrier (SLC) superfamily are determinants of metformin pharmacokinetics, we evaluated the effects of promoter variants in organic ca...

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Bibliographic Details
Main Authors: Peixian Chen, Yumin Cao, Shenren Chen, Zhike Liu, Shiyi Chen, Yali Guo
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Biomedicines
Subjects:
metformin
single-nucleotide polymorphism
pharmacogenetics
type 2 diabetes mellitus
Online Access:https://www.mdpi.com/2227-9059/10/10/2546

Internet

https://www.mdpi.com/2227-9059/10/10/2546

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