Crystallization of Feline Coronavirus Mpro With GC376 Reveals Mechanism of Inhibition

Crystallization of Feline Coronavirus Mpro With GC376 Reveals Mechanism of Inhibition

Coronaviruses infect a variety of hosts in the animal kingdom, and while each virus is taxonomically different, they all infect their host via the same mechanism. The coronavirus main protease (Mpro, also called 3CLpro), is an attractive target for drug development due to its essential role in media...

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Bibliographic Details
Main Authors: Jimmy Lu, Sizhu Amelia Chen, Muhammad Bashir Khan, Raelynn Brassard, Elena Arutyunova, Tess Lamer, Wayne Vuong, Conrad Fischer, Howard S. Young, John C. Vederas, M. Joanne Lemieux
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Chemistry
Subjects:
3CLpro
coronavirus
feline infectious peritonitis (FIP)
FCoV
protease
GC376
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.852210/full

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https://www.frontiersin.org/articles/10.3389/fchem.2022.852210/full

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