Thermodynamic and experimental analysis of drug nanoparticles preparation using supercritical thermal processing: Solubility of Chlorothiazide in different Co-solvents
Background/purpose: Chlorothiazide is a well-known diuretic and an antihypertensive drug with poor solubility and permeability and thus low bioavailability. Producing nanoparticles of this drug via a suitable supercritical method can enhance its therapeutic efficiency. For this purpose, supercritica...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Case Studies in Thermal Engineering |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214157X2300518X |