From purines to purinergic signalling: molecular functions and human diseases

Abstract Purines and their derivatives, most notably adenosine and ATP, are the key molecules controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these purines support, as chemical messengers, purinergic transmission throughout tissues and species. Purines act as endogen...

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Bibliographic Details
Main Authors: Zhao Huang, Na Xie, Peter Illes, Francesco Di Virgilio, Henning Ulrich, Alexey Semyanov, Alexei Verkhratsky, Beata Sperlagh, Shu-Guang Yu, Canhua Huang, Yong Tang
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-021-00553-z