Kinome‐Wide Synthetic Lethal Screen Identifies PANK4 as a Modulator of Temozolomide Resistance in Glioblastoma

Kinome‐Wide Synthetic Lethal Screen Identifies PANK4 as a Modulator of Temozolomide Resistance in Glioblastoma

Abstract Temozolomide (TMZ) represents the cornerstone of therapy for glioblastoma (GBM). However, acquisition of resistance limits its therapeutic potential. The human kinome is an undisputable source of druggable targets, still, current knowledge remains confined to a limited fraction of it, with...

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Bibliographic Details
Main Authors: Viviana Vella, Angeliki Ditsiou, Anna Chalari, Murat Eravci, Sarah K. Wooller, Teresa Gagliano, Cecilia Bani, Emanuela Kerschbamer, Christos Karakostas, Bin Xu, Yongchang Zhang, Frances M.G. Pearl, Gianluca Lopez, Ling Peng, Justin Stebbing, Apostolos Klinakis, Georgios Giamas
Format: Article
Language:English
Published: Wiley 2024-04-01
Series:Advanced Science
Subjects:
cellular detoxification
DUF89 domain
GBM
kinome‐wide RNAi screen
PANK4
TMT‐based quantitative proteomics
Online Access:https://doi.org/10.1002/advs.202306027

Internet

https://doi.org/10.1002/advs.202306027

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