LncRNA MIR4435-2HG mediates cisplatin resistance in HCT116 cells by regulating Nrf2 and HO-1.

<h4>Purpose</h4>Cisplatin resistance is still a serious problem in the clinic. However, the underlying mechanism remains unknown. In our study, we investigated cisplatin resistance by using the cisplatin-resistant cell line HCT116R.<h4>Methods</h4>The HCT116 cell line, a colo...

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Bibliographic Details
Main Authors: Ping Luo, Shugui Wu, Kaibao Ji, Xia Yuan, Hongmi Li, Jinping Chen, Yunfei Tian, Yang Qiu, Xiaoming Zhong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0223035