Molecular structures and conformations of protocadherin-15 and its complexes on stereocilia elucidated by cryo-electron tomography

Molecular structures and conformations of protocadherin-15 and its complexes on stereocilia elucidated by cryo-electron tomography

Mechanosensory transduction (MT), the conversion of mechanical stimuli into electrical signals, underpins hearing and balance and is carried out within hair cells in the inner ear. Hair cells harbor actin-filled stereocilia, arranged in rows of descending heights, where the tips of stereocilia are c...

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Bibliographic Details
Main Authors: Johannes Elferich, Sarah Clark, Jingpeng Ge, April Goehring, Aya Matsui, Eric Gouaux
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-12-01
Series:eLife
Subjects:
hearing
hair cells
mechanosensory transduction
PCDH15
CDH23
cryo-electron tomography
Online Access:https://elifesciences.org/articles/74512

Internet

https://elifesciences.org/articles/74512

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