Molecular structures and conformations of protocadherin-15 and its complexes on stereocilia elucidated by cryo-electron tomography
Mechanosensory transduction (MT), the conversion of mechanical stimuli into electrical signals, underpins hearing and balance and is carried out within hair cells in the inner ear. Hair cells harbor actin-filled stereocilia, arranged in rows of descending heights, where the tips of stereocilia are c...
Main Authors: | Johannes Elferich, Sarah Clark, Jingpeng Ge, April Goehring, Aya Matsui, Eric Gouaux |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2021-12-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/74512 |
Similar Items
-
Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5
by: Jingpeng Ge, et al.
Published: (2018-08-01) -
Expanding the genetic and clinical characteristics of Protocadherin 19 gene mutations
by: Giovanni Battista Dell’Isola, et al.
Published: (2022-08-01) -
Primary Cilia: Highly Sophisticated Biological Sensors
by: Wissam A. Abou Alaiwi, et al.
Published: (2009-09-01) -
Identification of four novel variants in the CDH23 gene from four affected families with hearing loss
by: Baoling Kang, et al.
Published: (2022-11-01) -
Epigenetic Silencing of the Protocadherin Family Member PCDH-γ-All in Astrocytomas
by: Anke Waha, et al.
Published: (2005-03-01)