Intraperitoneal administration of mRNA encoding interleukin-12 for immunotherapy in peritoneal carcinomatosis

Intraperitoneal administration of mRNA encoding interleukin-12 for immunotherapy in peritoneal carcinomatosis

Abstract Peritoneal carcinomatosis is an advanced stage of cancer with very limited treatment options. Locoregional immunotherapy is being evaluated as a way to improve efficacy and limit toxicity. This study assessed the efficacy of a cationic polymer/lipid-based transfection compound in delivering...

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Bibliographic Details
Main Authors: Leire Arrizabalaga, Claudia Augusta Di Trani, Myriam Fernández-Sendin, Ángela Bella, Joan Salvador Russo-Cabrera, Celia Gomar, Nuria Ardaiz, Virginia Belsue, José González-Gomariz, Sara Zalba, Adrián Gil-Korilis, Maria J. Garrido, Ignacio Melero, Fernando Aranda, Pedro Berraondo
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Nanobiotechnology
Subjects:
mRNA
Peritoneal carcinomatosis
Locoregional treatment
Interleukin-12
Cancer immunotherapy
Online Access:https://doi.org/10.1186/s12951-025-03196-2

Internet

https://doi.org/10.1186/s12951-025-03196-2

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