FGF21 Reduces Lipid Accumulation in Bovine Hepatocytes by Enhancing Lipid Oxidation and Reducing Lipogenesis via AMPK Signaling

FGF21 Reduces Lipid Accumulation in Bovine Hepatocytes by Enhancing Lipid Oxidation and Reducing Lipogenesis via AMPK Signaling

During the periparturient period, dairy cows suffer drastic metabolic stress because of plasma increased non-esterified fatty acids (NEFAs) that stem from a negative energy balance. Fibroblast growth factor 21 (FGF21) is a hepatokine that activates the AMP-activated protein kinase (AMPK) signaling p...

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Bibliographic Details
Main Authors: Yezi Kong, Chenxu Zhao, Panpan Tan, Siqi Liu, Yan Huang, Fangyuan Zeng, Pingjun Ma, Yazhou Guo, Baoyu Zhao, Jianguo Wang
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Animals
Subjects:
bovine hepatocytes
lipid metabolism
fibroblast growth factor 21
AMPK pathway
dairy cows
Online Access:https://www.mdpi.com/2076-2615/12/7/939

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https://www.mdpi.com/2076-2615/12/7/939

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