Evaluation of the Prognostic Value of Low-Frequency KRAS Mutation Detection in Circulating Tumor DNA of Patients with Metastatic Colorectal Cancer

Evaluation of the Prognostic Value of Low-Frequency KRAS Mutation Detection in Circulating Tumor DNA of Patients with Metastatic Colorectal Cancer

<i>KRAS</i> mutation in tumor tissue is a well-known predictor of resistance to the treatment of anti-EGFR antibodies in metastatic colorectal cancers (mCRC). However, the prognostic value of low-frequency plasma circulating tumor DNA (ctDNA) <i>KRAS</i> mutation in predictin...

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Bibliographic Details
Main Authors: Chien-Yu Lin, Ming-Yin Shen, William Tzu-Liang Chen, Chin-An Yang
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Journal of Personalized Medicine
Subjects:
circulating tumor DNA (ctDNA)
low-frequency KRAS mutation
metastatic colorectal cancer (mCRC)
anti-EGFR therapy
next-generation sequencing (NGS)
Online Access:https://www.mdpi.com/2075-4426/13/7/1051

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https://www.mdpi.com/2075-4426/13/7/1051

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