Synthetic lethality of drug-induced polyploidy and BCL-2 inhibition in lymphoma

Synthetic lethality of drug-induced polyploidy and BCL-2 inhibition in lymphoma

Genomic instability occurs infrequently in in diffuse large B cell lymphoma (DLBCL), suggesting a therapeutic vulnerability. Here, the authors identify a synergistic combination between the induction of polyploidy by a PLK4 inhibitor and a BCL-2 inhibitor in DLBCL.

Bibliographic Details
Main Authors: Ana Portelinha, Mariana da Silva Ferreira, Tatiana Erazo, Man Jiang, Zahra Asgari, Elisa de Stanchina, Anas Younes, Hans-Guido Wendel
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-37216-2

Internet

https://doi.org/10.1038/s41467-023-37216-2

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