Mitochondrial oxidative stress regulates LonP1-TDP-43 pathway and rises mitochondrial damage in carbon tetrachloride-induced liver fibrosis

Mitochondrial oxidative stress regulates LonP1-TDP-43 pathway and rises mitochondrial damage in carbon tetrachloride-induced liver fibrosis

Carbon tetrachloride (CCl4)-mediated liver damage has been well recognized, but the sources and mechanisms of mitochondrial damage during this progress still remain poorly understood. Accumulating evidence has revealed that LonP1-TDP-43 pathway affect proper mitochondrial integrity and function in n...

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Bibliographic Details
Main Authors: Shulin Shan, Zhidan Liu, Shuai Wang, Zhaoxiong Liu, Shihua Chao, Cuiqin Zhang, Ming Li, Fuyong Song
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Ecotoxicology and Environmental Safety
Subjects:
LonP1
TDP-43
Mitochondrial dysfunction
Liver fibrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651323009132

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http://www.sciencedirect.com/science/article/pii/S0147651323009132

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