Myeloid-derived suppressor cells promote tumor growth and sorafenib resistance by inducing FGF1 upregulation and fibrosis

Myeloid-derived suppressor cells promote tumor growth and sorafenib resistance by inducing FGF1 upregulation and fibrosis

Background: Considerable evidence implicates myeloid-derived suppressor cells (MDSCs) promote tumor progression and drug resistance. Sorafenib is the standard first-line therapy for advanced hepatocellular carcinoma (HCC). Clinical evidence indicates that sorafenib resistance is associated with incr...

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Bibliographic Details
Main Authors: Xue Deng, Xueyan Li, Xuan Guo, Yantong Lu, Yingjie Xie, Xuhui Huang, Juze Lin, Wei Tan, Changjun Wang
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Myeloid cells
Hepatocellular carcinoma
Sorafenib
Fibroblast cells
Combination therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558622000173

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http://www.sciencedirect.com/science/article/pii/S1476558622000173

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