Can harmful lifestyle, obesity and weight changes increase the risk of breast cancer in BRCA 1 and BRCA 2 mutation carriers? A Mini review
Abstract Background and aim The BRCA 1 and BRCA 2 genes are associated with an inherited susceptibility to breast cancer with a cumulative risk of 60% in BRCA 1 mutation carriers and of 30% in BRCA 2 mutation carriers. Several lifestyle factors could play a role in determining an individual’s risk o...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-10-01
|
| Series: | Hereditary Cancer in Clinical Practice |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13053-021-00199-6 |
| _version_ | 1818938199315054592 |
|---|---|
| author | A. Daniele R. Divella B. Pilato S. Tommasi P. Pasanisi M. Patruno M. Digennaro C. Minoia M. Dellino S. Pisconti P. Casamassima E. Savino A. V. Paradiso |
| author_facet | A. Daniele R. Divella B. Pilato S. Tommasi P. Pasanisi M. Patruno M. Digennaro C. Minoia M. Dellino S. Pisconti P. Casamassima E. Savino A. V. Paradiso |
| author_sort | A. Daniele |
| collection | DOAJ |
| description | Abstract Background and aim The BRCA 1 and BRCA 2 genes are associated with an inherited susceptibility to breast cancer with a cumulative risk of 60% in BRCA 1 mutation carriers and of 30% in BRCA 2 mutation carriers. Several lifestyle factors could play a role in determining an individual’s risk of breast cancer. Obesity, changes in body size or unhealthy lifestyle habits such as smoking, alcohol consumption and physical inactivity have been evaluated as possible determinants of breast cancer risk. The aim of this study was to explore the current understanding of the role of harmful lifestyle and obesity or weight change in the development of breast cancer in female carriers of BRCA 1/2 mutations. Methods Articles were identified from MEDLINE in October 2020 utilizing related keywords; they were then read and notes, study participants, measures, data analysis and results were used to write this review. Results Studies with very large case series have been carried out but only few of them have shown consistent results. Additional research would be beneficial to better determine the actual role and impact of such factors. |
| first_indexed | 2024-12-20T06:04:03Z |
| format | Article |
| id | doaj.art-10d63fca6e70409b88754191b056e6a2 |
| institution | Directory Open Access Journal |
| issn | 1897-4287 |
| language | English |
| last_indexed | 2024-12-20T06:04:03Z |
| publishDate | 2021-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Hereditary Cancer in Clinical Practice |
| spelling | doaj.art-10d63fca6e70409b88754191b056e6a22022-12-21T19:50:51ZengBMCHereditary Cancer in Clinical Practice1897-42872021-10-011911810.1186/s13053-021-00199-6Can harmful lifestyle, obesity and weight changes increase the risk of breast cancer in BRCA 1 and BRCA 2 mutation carriers? A Mini reviewA. Daniele0R. Divella1B. Pilato2S. Tommasi3P. Pasanisi4M. Patruno5M. Digennaro6C. Minoia7M. Dellino8S. Pisconti9P. Casamassima10E. Savino11A. V. Paradiso12Experimental Oncology and Biobank Management Unit, IRCCS Istituto Tumori “Giovanni Paolo II” BariExperimental Oncology and Biobank Management Unit, IRCCS Istituto Tumori “Giovanni Paolo II” BariMolecular Diagnostics and Pharmacogenetics Unit, IRCCS Istituto Tumori “Giovanni Paolo II” BariMolecular Diagnostics and Pharmacogenetics Unit, IRCCS Istituto Tumori “Giovanni Paolo II” BariEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di MilanoExperimental Oncology, Center for Study of Heredo-Familial Tumors, IRCCS- Istituto “Tumori “Giovanni Paolo II”Experimental Oncology, Center for Study of Heredo-Familial Tumors, IRCCS- Istituto “Tumori “Giovanni Paolo II”Hematology Unit, IRCCS Istituto Tumori “Giovanni Paolo II” BariGynecologic Oncology Unit, IRCCS Istituto Tumori “Giovanni Paolo II” BariMedical Oncology Unit, Ospedale MoscatiClinical Pathology Laboratory Unit, IRCCS Istituto Tumori “Giovanni Paolo II” BariClinical Pathology Laboratory Unit, IRCCS Istituto Tumori “Giovanni Paolo II” BariScience Direction, IRCCS Istituto Tumori “Giovanni Paolo II” BariAbstract Background and aim The BRCA 1 and BRCA 2 genes are associated with an inherited susceptibility to breast cancer with a cumulative risk of 60% in BRCA 1 mutation carriers and of 30% in BRCA 2 mutation carriers. Several lifestyle factors could play a role in determining an individual’s risk of breast cancer. Obesity, changes in body size or unhealthy lifestyle habits such as smoking, alcohol consumption and physical inactivity have been evaluated as possible determinants of breast cancer risk. The aim of this study was to explore the current understanding of the role of harmful lifestyle and obesity or weight change in the development of breast cancer in female carriers of BRCA 1/2 mutations. Methods Articles were identified from MEDLINE in October 2020 utilizing related keywords; they were then read and notes, study participants, measures, data analysis and results were used to write this review. Results Studies with very large case series have been carried out but only few of them have shown consistent results. Additional research would be beneficial to better determine the actual role and impact of such factors.https://doi.org/10.1186/s13053-021-00199-6BRCA mutationLifestyleObesityBRCA-associated cancer |
| spellingShingle | A. Daniele R. Divella B. Pilato S. Tommasi P. Pasanisi M. Patruno M. Digennaro C. Minoia M. Dellino S. Pisconti P. Casamassima E. Savino A. V. Paradiso Can harmful lifestyle, obesity and weight changes increase the risk of breast cancer in BRCA 1 and BRCA 2 mutation carriers? A Mini review Hereditary Cancer in Clinical Practice BRCA mutation Lifestyle Obesity BRCA-associated cancer |
| title | Can harmful lifestyle, obesity and weight changes increase the risk of breast cancer in BRCA 1 and BRCA 2 mutation carriers? A Mini review |
| title_full | Can harmful lifestyle, obesity and weight changes increase the risk of breast cancer in BRCA 1 and BRCA 2 mutation carriers? A Mini review |
| title_fullStr | Can harmful lifestyle, obesity and weight changes increase the risk of breast cancer in BRCA 1 and BRCA 2 mutation carriers? A Mini review |
| title_full_unstemmed | Can harmful lifestyle, obesity and weight changes increase the risk of breast cancer in BRCA 1 and BRCA 2 mutation carriers? A Mini review |
| title_short | Can harmful lifestyle, obesity and weight changes increase the risk of breast cancer in BRCA 1 and BRCA 2 mutation carriers? A Mini review |
| title_sort | can harmful lifestyle obesity and weight changes increase the risk of breast cancer in brca 1 and brca 2 mutation carriers a mini review |
| topic | BRCA mutation Lifestyle Obesity BRCA-associated cancer |
| url | https://doi.org/10.1186/s13053-021-00199-6 |
| work_keys_str_mv | AT adaniele canharmfullifestyleobesityandweightchangesincreasetheriskofbreastcancerinbrca1andbrca2mutationcarriersaminireview AT rdivella canharmfullifestyleobesityandweightchangesincreasetheriskofbreastcancerinbrca1andbrca2mutationcarriersaminireview AT bpilato canharmfullifestyleobesityandweightchangesincreasetheriskofbreastcancerinbrca1andbrca2mutationcarriersaminireview AT stommasi canharmfullifestyleobesityandweightchangesincreasetheriskofbreastcancerinbrca1andbrca2mutationcarriersaminireview AT ppasanisi canharmfullifestyleobesityandweightchangesincreasetheriskofbreastcancerinbrca1andbrca2mutationcarriersaminireview AT mpatruno canharmfullifestyleobesityandweightchangesincreasetheriskofbreastcancerinbrca1andbrca2mutationcarriersaminireview AT mdigennaro canharmfullifestyleobesityandweightchangesincreasetheriskofbreastcancerinbrca1andbrca2mutationcarriersaminireview AT cminoia canharmfullifestyleobesityandweightchangesincreasetheriskofbreastcancerinbrca1andbrca2mutationcarriersaminireview AT mdellino canharmfullifestyleobesityandweightchangesincreasetheriskofbreastcancerinbrca1andbrca2mutationcarriersaminireview AT spisconti canharmfullifestyleobesityandweightchangesincreasetheriskofbreastcancerinbrca1andbrca2mutationcarriersaminireview AT pcasamassima canharmfullifestyleobesityandweightchangesincreasetheriskofbreastcancerinbrca1andbrca2mutationcarriersaminireview AT esavino canharmfullifestyleobesityandweightchangesincreasetheriskofbreastcancerinbrca1andbrca2mutationcarriersaminireview AT avparadiso canharmfullifestyleobesityandweightchangesincreasetheriskofbreastcancerinbrca1andbrca2mutationcarriersaminireview |