Oncolytic adenoviruses expressing checkpoint inhibitors for cancer therapy

Oncolytic adenoviruses expressing checkpoint inhibitors for cancer therapy

Abstract Despite the remarkable success of immune checkpoint inhibitors (ICIs), primary resistance to ICIs causes only subsets of patients to achieve durable responses due to the complex tumor microenvironment (TME). Oncolytic viruses (OVs) can overcome the immunosuppressive TME and promote systemic...

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Bibliographic Details
Main Authors: Daoyuan Xie, Yaomei Tian, Die Hu, Yuanda Wang, Yuling Yang, Bailing Zhou, Rui Zhang, Zhixiang Ren, Mohan Liu, Jie Xu, Chunyan Dong, Binyan Zhao, Li Yang
Format: Article
Language:English
Published: Nature Publishing Group 2023-11-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-023-01683-2

Internet

https://doi.org/10.1038/s41392-023-01683-2

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