Spatial Proteomic Analysis of Isogenic Metastatic Colorectal Cancer Cells Reveals Key Dysregulated Proteins Associated with Lymph Node, Liver, and Lung Metastasis

Spatial Proteomic Analysis of Isogenic Metastatic Colorectal Cancer Cells Reveals Key Dysregulated Proteins Associated with Lymph Node, Liver, and Lung Metastasis

Metastasis is the primary cause of colorectal cancer (CRC) death. The liver and lung, besides adjacent lymph nodes, are the most common sites of metastasis. Here, we aimed to study the lymph nodes, liver, and lung CRC metastasis by quantitative spatial proteomics analysis using CRC cell-based models...

Full description

Bibliographic Details
Main Authors: Guillermo Solís-Fernández, Ana Montero-Calle, Javier Martínez-Useros, Álvaro López-Janeiro, Vivian de los Ríos, Rodrigo Sanz, Jana Dziakova, Elena Milagrosa, María Jesús Fernández-Aceñero, Alberto Peláez-García, José Ignacio Casal, Johan Hofkens, Susana Rocha, Rodrigo Barderas
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cells
Subjects:
colorectal cancer
metastasis
spatial proteomics
quantitative proteomics
TMT
mass-spectrometry
Online Access:https://www.mdpi.com/2073-4409/11/3/447

Internet

https://www.mdpi.com/2073-4409/11/3/447

Similar Items