The antibiotic furagin and its derivatives are isoform-selective human carbonic anhydrase inhibitors

The antibiotic furagin and its derivatives are isoform-selective human carbonic anhydrase inhibitors

The clinically used antibiotic Furagin and its derivatives possess inhibitory activity on human (h) carbonic anhydrases (CA, EC 4.2.1.1), some of which are highly expressed in various tissues and malignancies (hCA IX/XII). Furagin exhibited good hCA IX and XII inhibition with KIs of 260 and 57 nM, r...

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Bibliographic Details
Main Authors: Aleksandrs Pustenko, Alessio Nocentini, Paola Gratteri, Alessandro Bonardi, Igor Vozny, Raivis Žalubovskis, Claudiu T. Supuran
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
carbonic anhydrase inhibitors
molecular dynamics
furagin
hydantoin
synthesis
Online Access:http://dx.doi.org/10.1080/14756366.2020.1752201

Internet

http://dx.doi.org/10.1080/14756366.2020.1752201

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