Immune-mediated neurodegenerative trait provoked by multimodal derepression of long-interspersed nuclear element-1
Summary: Neurodegeneration is a process involving both cell autonomous and non-cell autonomous neuron loss, followed by a collapse of neural networks, but its pathogenesis is poorly understood. We have previously demonstrated that Eomes-positive helper T (Eomes + Th) cells recognizing LINE-1(L1)-der...
Main Authors: | Fumio Takahashi, Chenyang Zhang, Hirohiko Hohjoh, Ben Raveney, Takashi Yamamura, Nobuhiro Hayashi, Shinji Oki |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2022-05-01
|
Series: | iScience |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S258900422200548X |
Similar Items
-
Pathogenic Microglia Orchestrate Neurotoxic Properties of Eomes-Expressing Helper T Cells
by: Chenyang Zhang, et al.
Published: (2023-03-01) -
Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation
by: Tomohisa Toda, et al.
Published: (2024-02-01) -
Nuclear receptor NR4A2 orchestrates Th17 cell-mediated autoimmune inflammation via IL-21 signalling.
by: Ben J E Raveney, et al.
Published: (2013-01-01) -
M2 microglia activation and proNGF inhibition : Possible Mechanisms Behind Cognitive Improvements by Low-Dose Ionizing Radiation on Alzheimer's Disease; A Literature Review
by: Alifa, Hasna Noor
Published: (2022) -
Silencing miR-21-5p in sensory neurons reverses neuropathic allodynia via activation of TGF-β–related pathway in macrophages
by: Lynda Zeboudj, et al.
Published: (2023-06-01)