Mutability of druggable kinases and pro-inflammatory cytokines by their proximity to telomeres and A+T content

Mutations of protein kinases and cytokines are common and can cause cancer and other diseases. However, our understanding of the mutability in these genes remains rudimentary. Therefore, given previously known factors which are associated with high mutation rates, we analyzed how many genes encoding...

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Bibliographic Details
Main Authors: Ian McKnight, Regan Raines, Hunter White, Nasim Nosoudi, Chan Lee, Peter H. U. Lee, Joon W. Shim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138820/?tool=EBI