NIPA (Nuclear Interaction Partner of ALK) Is Crucial for Effective NPM-ALK Mediated Lymphomagenesis

NIPA (Nuclear Interaction Partner of ALK) Is Crucial for Effective NPM-ALK Mediated Lymphomagenesis

The NPM-ALK fusion kinase is expressed in 60% of systemic anaplastic large-cell lymphomas (ALCL). A Nuclear Interaction Partner of ALK (NIPA) was identified as a binding partner of NPM-ALK. To identify the precise role of NIPA for NPM-ALK-driven lymphomagenesis, we investigated various NPM-ALK+ cell...

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Bibliographic Details
Main Authors: Stefanie Kreutmair, Lena Johanna Lippert, Cathrin Klingeberg, Corinna Albers-Leischner, Salome Yacob, Valeria Shlyakhto, Tony Mueller, Alina Mueller-Rudorf, Chuanjiang Yu, Sivahari Prasad Gorantla, Cornelius Miething, Justus Duyster, Anna Lena Illert
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Oncology
Subjects:
NIPA
NPM-ALK
anaplastic large cell lymphoma
lymphomagenesis
transplantation mouse model
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.875117/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.875117/full

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