Episomal Nonviral Gene Therapy Vectors Slow Progression of Atherosclerosis in a Model of Familial Hypercholesterolemia

Episomal Nonviral Gene Therapy Vectors Slow Progression of Atherosclerosis in a Model of Familial Hypercholesterolemia

Familial hypercholesterolemia (FH) is a life-threatening genetic disorder characterized by elevated levels of plasma low-density lipoprotein cholesterol (LDL-cholesterol). Current attempts at gene therapy for FH have been limited by the use of strong heterologous promoters which lack genomic DNA ele...

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Bibliographic Details
Main Authors: Alastair G Kerr, Lawrence CS Tam, Ashley B Hale, Milena Cioroch, Gillian Douglas, Keith M Channon, Richard Wade-Martins
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
familial hypercholesterolemia
LDL-cholesterol
nonviral gene therapy
Ldlr-/- mouse
miRNA
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253117301051

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http://www.sciencedirect.com/science/article/pii/S2162253117301051

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