Selective Pressure by Rifampicin Modulates Mutation Rates and Evolutionary Trajectories of Mycobacterial Genomes

Selective Pressure by Rifampicin Modulates Mutation Rates and Evolutionary Trajectories of Mycobacterial Genomes

ABSTRACT Resistance to the frontline antibiotic rifampicin constitutes a challenge to the treatment and control of tuberculosis. Here, we analyzed the mutational landscape of Mycobacterium smegmatis during long-term evolution with increasing concentrations of rifampicin, using a mutation accumulatio...

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Bibliographic Details
Main Authors: E. Cebrián-Sastre, A. Chiner-Oms, R. Torres-Pérez, I. Comas, J. C. Oliveros, J. Blázquez, A. Castañeda-García
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:Microbiology Spectrum
Subjects:
DNA repair
Mycobacterium
Mycobacterium smegmatis
antibiotic resistance
drug resistance evolution
evolution
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01017-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.01017-23

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