Selective Pressure by Rifampicin Modulates Mutation Rates and Evolutionary Trajectories of Mycobacterial Genomes

Selective Pressure by Rifampicin Modulates Mutation Rates and Evolutionary Trajectories of Mycobacterial Genomes

ABSTRACT Resistance to the frontline antibiotic rifampicin constitutes a challenge to the treatment and control of tuberculosis. Here, we analyzed the mutational landscape of Mycobacterium smegmatis during long-term evolution with increasing concentrations of rifampicin, using a mutation accumulatio...

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Detalles Bibliográficos
Main Authors: E. Cebrián-Sastre, A. Chiner-Oms, R. Torres-Pérez, I. Comas, J. C. Oliveros, J. Blázquez, A. Castañeda-García
Formato: Artigo
Idioma:English
Publicado: American Society for Microbiology 2023-08-01
Series:Microbiology Spectrum
Subjects:
DNA repair
Mycobacterium
Mycobacterium smegmatis
antibiotic resistance
drug resistance evolution
evolution
Acceso en liña:https://journals.asm.org/doi/10.1128/spectrum.01017-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.01017-23

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