Selective Pressure by Rifampicin Modulates Mutation Rates and Evolutionary Trajectories of Mycobacterial Genomes
ABSTRACT Resistance to the frontline antibiotic rifampicin constitutes a challenge to the treatment and control of tuberculosis. Here, we analyzed the mutational landscape of Mycobacterium smegmatis during long-term evolution with increasing concentrations of rifampicin, using a mutation accumulatio...
| Main Authors: | , , , , , , |
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| פורמט: | Article |
| שפה: | English |
| יצא לאור: |
American Society for Microbiology
2023-08-01
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| סדרה: | Microbiology Spectrum |
| נושאים: | |
| גישה מקוונת: | https://journals.asm.org/doi/10.1128/spectrum.01017-23 |