Selective Pressure by Rifampicin Modulates Mutation Rates and Evolutionary Trajectories of Mycobacterial Genomes
ABSTRACT Resistance to the frontline antibiotic rifampicin constitutes a challenge to the treatment and control of tuberculosis. Here, we analyzed the mutational landscape of Mycobacterium smegmatis during long-term evolution with increasing concentrations of rifampicin, using a mutation accumulatio...
| Huvudupphovsmän: | , , , , , , |
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| Materialtyp: | Artikel |
| Språk: | English |
| Publicerad: |
American Society for Microbiology
2023-08-01
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| Serie: | Microbiology Spectrum |
| Ämnen: | |
| Länkar: | https://journals.asm.org/doi/10.1128/spectrum.01017-23 |