Selective Pressure by Rifampicin Modulates Mutation Rates and Evolutionary Trajectories of Mycobacterial Genomes

Selective Pressure by Rifampicin Modulates Mutation Rates and Evolutionary Trajectories of Mycobacterial Genomes

ABSTRACT Resistance to the frontline antibiotic rifampicin constitutes a challenge to the treatment and control of tuberculosis. Here, we analyzed the mutational landscape of Mycobacterium smegmatis during long-term evolution with increasing concentrations of rifampicin, using a mutation accumulatio...

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Những tác giả chính: E. Cebrián-Sastre, A. Chiner-Oms, R. Torres-Pérez, I. Comas, J. C. Oliveros, J. Blázquez, A. Castañeda-García
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: American Society for Microbiology 2023-08-01
Loạt:Microbiology Spectrum
Những chủ đề:
DNA repair
Mycobacterium
Mycobacterium smegmatis
antibiotic resistance
drug resistance evolution
evolution
Truy cập trực tuyến:https://journals.asm.org/doi/10.1128/spectrum.01017-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.01017-23

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