Manipulation of the Tubulin Code Alters Directional Cell Migration and Ciliogenesis

Manipulation of the Tubulin Code Alters Directional Cell Migration and Ciliogenesis

Conjunction of epithelial cells into monolayer sheets implies the ability to migrate and to undergo apicobasal polarization. Both processes comprise reorganization of cytoskeletal elements and rearrangements of structural protein interactions. We modulated expression of tubulin tyrosin ligase (TTL),...

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Bibliographic Details
Main Authors: Manuel Müller, Lena Gorek, Natalia Kamm, Ralf Jacob
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Tubulin Tyrosine Ligase (TTL)
microtubule tyrosination/detyrosination
Focal Adhesion (FA)
directional cell migration
epithelial morphogenesis
primary cilia
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.901999/full

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https://www.frontiersin.org/articles/10.3389/fcell.2022.901999/full

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