Lysine tRNA fragments and miR-194-5p co-regulate hepatic steatosis via β-Klotho and perilipin 2

Lysine tRNA fragments and miR-194-5p co-regulate hepatic steatosis via β-Klotho and perilipin 2

Objective: Non-alcoholic fatty liver disease (NAFLD) involves hepatic accumulation of intracellular lipid droplets via incompletely understood processes. Here, we report distinct and cooperative NAFLD roles of LysTTT-5′tRF transfer RNA fragments and microRNA miR-194-5p. Methods: Combined use of diet...

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Bibliographic Details
Main Authors: Yonat Tzur, Katarzyna Winek, Nimrod Madrer, Serafima Dubnov, Estelle R. Bennett, David S. Greenberg, Geula Hanin, Asaad Gammal, Joseph Tam, Isaiah T. Arkin, Iddo Paldor, Hermona Soreq
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Molecular Metabolism
Subjects:
KLB
LysTTT-5′tRFs
microRNAs
miR-194-5p
NAFLD
PLIN2
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877823001904

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http://www.sciencedirect.com/science/article/pii/S2212877823001904

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