MicroRNA-494 augments fibrotic transformation of human retinal pigment epithelial cells and targets p27 with cell-type specificity

MicroRNA-494 augments fibrotic transformation of human retinal pigment epithelial cells and targets p27 with cell-type specificity

Epiretinal membranes (ERMs) are the result of fibro-cellular proliferation that cause distortion and impairment of central vision. We hypothesized that select microRNAs (miRs) regulate retinal fibro-proliferation and ERM formation. Following IRB approval, a pilot study was performed in patients pres...

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Bibliographic Details
Main Authors: Theodore Leng, Georgia Kamboj, Xiaoyun Sun, Heather Chang, Prisha Davda, Majesty Greer, Creed M. Stary
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Ophthalmology
Subjects:
MiR-494
RPE
Müller cell
ERM
miR
miRNA
Online Access:https://www.frontiersin.org/articles/10.3389/fopht.2023.1168650/full

Internet

https://www.frontiersin.org/articles/10.3389/fopht.2023.1168650/full

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